In close collaboration with our pharmaceutical and agrochemical partners, our research will bring us our essential medicines and food while reducing the impact on the environment.
Our research has developed new and sustainable routes to small organic molecules, essential for the pharmaceutical and agrochemical industries. For example, catalytic meta C-H functionalisation has allowed us to synthesise difficult to access drug like cores that previously would have taken multiple transformations and generated large amounts of waste.
Research in our labs has also seen the development of catalytic transformations using abundant, low cost and non-toxic metals. We have recently synthesised three pharmaceuticals using copper catalysis to construct the key drug cores, proving that sustainable catalysts can effectively replace the heavily used yet dwindling Platinum Group metals.
Professor Chris Frost
Key Research Papers
ACS Catal., 2016, 6, 5220.
Cat. Sci. Tech., 2016, 6, 7068.
ACS Cent. Sci., 2015, 1, 418.
Angew. Chem. Int. Ed., 2015, 54, 10944.
Chem. Commun., 2015, 51, 12807.
Org. Lett., 2014, 16, 5020.
J. Am. Chem. Soc., 2011, 133, 19298.