Our research has developed new and sustainable routes to small organic molecules, essential for the pharmaceutical and agrochemical industries.
For example, catalytic meta C-H functionalisation has allowed us to synthesise difficult to access drug like cores that previously would have taken multiple transformations and generated large amounts of waste.
Research in our labs has also seen the development of catalytic transformations using abundant, low cost and non-toxic metals. We have recently synthesised three pharmaceuticals using copper catalysis to construct the key drug cores, proving that sustainable catalysts can effectively replace the heavily used yet dwindling Platinum Group metals.
Professor Chris Frost
ACS Catal., 2016, 6, 5220
Cat. Sci. Tech., 2016, 6, 7068
ACS Cent. Sci., 2015, 1, 418
Angew. Chem. Int. Ed., 2015, 54, 10944
Chem. Commun., 2015, 51, 12807
Org. Lett., 2014, 16, 5020
J. Am. Chem. Soc., 2011, 133, 19298