Our research has developed new and sustainable routes to small organic molecules, essential for the pharmaceutical and agrochemical industries.

For example, catalytic meta C-H functionalisation has allowed us to synthesise difficult to access drug like cores that previously would have taken multiple transformations and generated large amounts of waste.

Research in our labs has also seen the development of catalytic transformations using abundant, low cost and non-toxic metals. We have recently synthesised three pharmaceuticals using copper catalysis to construct the key drug cores, proving that sustainable catalysts can effectively replace the heavily used yet dwindling Platinum Group metals.

Historically the development of novel routes to small organic molecules has been performed without regard to sustainability. As a result, these processes can generate large amounts of chemical waste and use expensive, rare metals. By placing sustainability at the Centre of our methodology development we are able to design from first principles, atom-economical, low waste and abundant metal based catalytic transformations.”
Professor Chris Frost

 

Outputs

ACS Catal., 2016, 6, 5220
Cat. Sci. Tech., 2016, 6, 7068
ACS Cent. Sci., 2015, 1, 418
Angew. Chem. Int. Ed., 2015, 54, 10944
Chem. Commun., 2015, 51, 12807
Org. Lett., 2014, 16, 5020
J. Am. Chem. Soc., 2011, 133, 19298

Industrial Partners

CSCT Students Involved

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